We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
Read More
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
Read More
9
Bone weakness solution
100 people found this helpful
Excellent! Magnesium has been a lifesaver for my bone weakness. It has improved muscle and heart functions and has strengthened my immune system. It’s a great find, even for preventative use.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 163 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
Read More
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
Read More
9
Bone weakness solution
100 people found this helpful
Excellent! Magnesium has been a lifesaver for my bone weakness. It has improved muscle and heart functions and has strengthened my immune system. It’s a great find, even for preventative use.
Read More
9
Joint pain improved
97 people found this helpful
I'm thrilled with this magnesium and use it for myself and my parents. It greatly calms their nervous system and enhances sleep quality. My mum often suffers from joint pain, and magnesium has notably alleviated her discomfort. It's well-absorbed and doesn’t cause diarrhoea. We take two tablets at night.
Read More
9
Helps cramps and headaches
80 people found this helpful
My headaches have disappeared and my blood pressure has normalised thanks to this magnesium. It also aids in relieving leg cramps and pain during my menstrual period.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, the time frame for seeing results from magnesium supplementation for bone pain can vary, but many individuals report noticeable improvements within a week. One user highlighted that after experiencing severe neck and shoulder bone pain for years, they felt a significant difference just a week after starting magnesium Read Review. Another user articulated a similar experience, noting that their knee bone pain significantly diminished after beginning the supplement and noted the need to reorder it shortly thereafter Read Review.
Several reviews indicate that effects can be seen even sooner. One user mentioned feeling pain relief just four days after starting the supplement, attributing it to a significant improvement in their mobility Read Review. Additionally, another user experiencing waist and back pain reported complete relief merely a week after beginning supplementation Read Review. Overall, if you are using magnesium for bone pain, consider monitoring your progress over the first week to gauge its effectiveness for your situation.
This supplement shows promise for alleviating bone pain based on several studies, although more extensive research is needed to fully support its efficacy. One notable study explored the effects of choline magnesium trisalicylate (CMT), which was tested against a placebo for pain relief in patients with metastatic cancer. The results indicated a significant reduction in pain just one hour after treatment, suggesting that CMT may be beneficial in managing bone pain, potentially aiding traditional opioid therapy [3]. However, additional comparisons did not yield statistically significant improvements, indicating that further investigation is warranted to confirm its overall effectiveness.
Moreover, another research effort focused on a novel drug delivery system combining denosumab and magnesium to treat conditions related to osteoporosis. While this framework exhibited good potential for drug release and showed biocompatibility encouraging cell growth, the study also highlighted the necessity of additional research to substantiate its effectiveness in real-world scenarios [1]. Overall, while there is scientific backing for the use of magnesium-based treatments and bisphosphonates in alleviating bone-related discomfort, particularly in specific populations like children with osteogenesis imperfecta [2], more robust clinical trials are needed to confirm these benefits for widespread use.
Users have reported a range of improvements in symptoms after incorporating magnesium supplementation into their routines. Many have highlighted significant alleviation of symptoms related to anxiety, fatigue, and chronic pain. One user mentioned that after suffering from anxiety and constant headaches for over two years, they experienced a remarkable transformation after starting magnesium, stating that their quality of life improved dramatically Read Review. Others have noted fast-acting results, with one user experiencing relief from calf pain and increased energy within a week Read Review.
Specific cases of joint and muscle pain reduction are prominent, with several individuals reporting notable improvements in conditions ranging from menstrual cramps to chronic neck and joint pain. For instance, one reviewer who suffered from neck and shoulder pain found that their symptoms significantly diminished just a week after starting magnesium Read Review. Additionally, another user with debilitating nerve pain stated that magnesium made such a substantial difference that they began recommending it to their family after just 18 days of use Read Review. These anecdotal experiences suggest that magnesium supplementation may lead to a variety of benefits, including improved mood, reduced pain, and better sleep quality, though individual results may vary.
Users have expressed positive experiences when combining magnesium supplementation with other dietary routines and supplements to manage bone and joint pain. For instance, one user noted that taking magnesium alongside Omega 3 enhanced their deep sleep and effectively reduced period cramps, ultimately decreasing their reliance on painkillers Read Review. Another user highlighted how including magnesium in their regimen, along with other vitamins, markedly improved their quality of life and alleviated joint pain after significant weight loss Read Review.
Additionally, there are indications that magnesium works synergistically with other elements like boron, which some users recognized as beneficial for muscle building and bone health Read Review. Several reviewers emphasize that magnesium not only serves as a standalone solution but also complements other treatments, providing relief from ailments ranging from menstrual cramps to chronic pain, underscoring its versatility when paired with other supplements Read Review. Overall, user feedback suggests that a multi-faceted approach can enhance the effectiveness of magnesium for managing bone pain.
While research on magnesium for treating bone pain is still evolving, a notable study indicates potential benefits from choline magnesium trisalicylate (CMT), which contains magnesium and specifically targets bone pain in metastatic cancer patients. In a controlled study, participants reported significant pain relief just one hour after taking CMT, though the overall effectiveness of CMT in terms of managing bone pain remains under investigation [3].
At this point, the optimal dose of magnesium for treating bone pain is not clearly established by research. Additional studies are needed to determine effective doses and verify if magnesium-based therapies can offer significant relief consistently. As findings like those from CMT suggest, magnesium could serve as a complementary treatment option alongside traditional pain management methods, but definitive dosage recommendations await further confirmation through extended clinical trials [1].
9
Significant relief
41 people found this helpful
More than wonderful! I have suffered from severe neck and shoulder bone pain for years; medications prescribed by my doctor failed to provide relief. Since starting this treatment, I felt a significant difference within a week. I only wish I’d discovered this sooner!
9
Effective for knees
14 people found this helpful
Since I started using this product, my knee bone pain has significantly diminished. I strongly recommend this to anyone experiencing joint pain. I plan to order it again.
10
Knee pain relief
26 people found this helpful
If you have arthritis or rheumatism, you must try this supplement. After enduring five knee surgeries, my movement was severely limited. Just four days after taking this magnesium supplement, I experienced remarkable results—no more pain, better than any painkillers I've tried. It transformed my mobility and comfort.
10
Cured bone pain
8 people found this helpful
I had been experiencing pain in my waist and back for ages. Suspecting a magnesium deficiency, I started taking it and within a week, I was completely cured! It's now an essential part of my routine. I can't recommend it enough.
9
Improved quality of life
720 people found this helpful
I am smiling at my boss and love my mother-in-law! For over two years, I've experienced symptoms like anxiety, fatigue, and constant headaches, which I attributed to a lack of magnesium. Initially, I hesitated to take it, thinking it was just an “age-old” remedy. However, magnesium supplementation has transformed me from a tired individual into a calm person. My meteorological dependence and tearfulness have vanished, and the quality of life has improved dramatically. I recommend magnesium for overall wellness and vitality.
9
Relieved leg pain
326 people found this helpful
I highly recommend magnesium! I take it daily with my husband after breakfast and dinner. Within a week, the heaviness and pain in my legs disappeared. As someone with a sedentary job, I experienced calf pain, but this miracle remedy has truly changed things. My husband also noticed less leg pain and increased energy. We even bought it for our parents, who reported greater endurance and less drowsiness. Truly an amazing product!
8
Reduced nerve pain
61 people found this helpful
I initially purchased this for my grandmother, who suffers from debilitating carpal and cubital tunnel issues. She has experienced significant numbness and pain, requiring immobilisers at night. For over two years, she endured incessant nerve pain and insomnia. After taking this magnesium for 18 days, she started recommending it to family, as it has greatly improved her situation and helped with better absorption.
9
Super supplement
9 people found this helpful
I take magnesium not only as an essential supplement for women but also for sleep, calming, and muscle soreness. It truly is a super supplement. It complements Omega 3 for deep sleep and helps with period cramps alongside turmeric, reducing the need for painkillers. After trying a different brand, I returned to this one due to its effectiveness. It's one of the top five supplements one should have in their life.
9
Eliminated joint pain
11 people found this helpful
As a bariatric patient, I lost considerable weight, leading to muscle weakness, joint pain, and insomnia. After introducing magnesium and other vitamins into my regimen, my quality of life has tremendously improved. My sleep quality has enhanced markedly, and the pain has subsided. I recommend this product; while a downside is taking four tablets, I find them worthwhile.
9
Muscle strengthening aid
17 people found this helpful
Excellent! This product contains magnesium with boron, fantastic for muscle building and bone health. It helps with deep sleep and reduces anxiety. Just be sure to take enough calcium as well.
9
No more pains
46 people found this helpful
Excellent! Love it. Thanks to this, my monthly bone pain has vanished! I take 400 mg daily each week before my period. I previously relied on ibuprofen, which often didn’t help. I now enjoy my dinners and recommend this to anyone struggling with menstrual cramps.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.